Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose

PURPOSE: The aim of this study was to ascertain whether the absolute bioavailability of oral imatinib (Glivec®) during steady state plasma pharmacokinetics in cancer patients could be determined through a concomitant intravenous administration of a single 100 μg microdose of deuterium labeled imatin...

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Dettagli Bibliografici
Pubblicato in:Eur J Clin Pharmacol
Autori principali: Roosendaal, Jeroen, Groenland, Stefanie L., Rosing, Hilde, Lucas, Luc, Venekamp, Nikkie, Nuijen, Bastiaan, Huitema, Alwin D. R., Beijnen, Jos H., Steeghs, Neeltje
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2020
Soggetti:
Clinical Trial
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351863/
https://ncbi.nlm.nih.gov/pubmed/32430518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-020-02888-y
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