Phase I pharmacological study of continuous chronomodulated capecitabine treatment

PURPOSE: Capecitabine is an oral pre-pro-drug of the anti-cancer drug 5-fluorouracil (5-FU). The biological activity of the 5-FU degrading enzyme, dihydropyrimidine dehydrogenase (DPD), and the target enzyme thymidylate synthase (TS), are subject to circadian rhythmicity in healthy volunteers. The a...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Roosendaal, Jeroen, Jacobs, Bart A. W., Pluim, Dick, Rosing, Hilde, de Vries, Niels, van Werkhoven, Erik, Nuijen, Bastiaan, Beijnen, Jos H., Huitema, Alwin D. R., Schellens, Jan H. M., Marchetti, Serena
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205843/
https://ncbi.nlm.nih.gov/pubmed/32382808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-020-02828-6
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