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Phase I pharmacological study of continuous chronomodulated capecitabine treatment
PURPOSE: Capecitabine is an oral pre-pro-drug of the anti-cancer drug 5-fluorouracil (5-FU). The biological activity of the 5-FU degrading enzyme, dihydropyrimidine dehydrogenase (DPD), and the target enzyme thymidylate synthase (TS), are subject to circadian rhythmicity in healthy volunteers. The a...
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| Vydáno v: | Pharm Res |
|---|---|
| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Springer US
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7205843/ https://ncbi.nlm.nih.gov/pubmed/32382808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-020-02828-6 |
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