Stable isotope‐labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

AIMS: Ibrutinib, an inhibitor of Bruton's tyrosine kinase, is used in the treatment of mantle cell lymphoma or chronic lymphocytic leukaemia. Ibrutinib undergoes extensive rapid oxidative metabolism mediated by cytochrome P450 3A both at the level of first pass and clearance, which might result...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: de Vries, Ronald, Smit, Johan W., Hellemans, Peter, Jiao, James, Murphy, Joseph, Skee, Donna, Snoeys, Jan, Sukbuntherng, Juthamas, Vliegen, Maarten, de Zwart, Loeckie, Mannaert, Erik, de Jong, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Clinical Trials
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833163/
https://ncbi.nlm.nih.gov/pubmed/26382728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12787
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