Stable isotope‐labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

AIMS: Ibrutinib, an inhibitor of Bruton's tyrosine kinase, is used in the treatment of mantle cell lymphoma or chronic lymphocytic leukaemia. Ibrutinib undergoes extensive rapid oxidative metabolism mediated by cytochrome P450 3A both at the level of first pass and clearance, which might result...

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Detalles Bibliográficos
Publicado en:Br J Clin Pharmacol
Main Authors: de Vries, Ronald, Smit, Johan W., Hellemans, Peter, Jiao, James, Murphy, Joseph, Skee, Donna, Snoeys, Jan, Sukbuntherng, Juthamas, Vliegen, Maarten, de Zwart, Loeckie, Mannaert, Erik, de Jong, Jan
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Clinical Trials
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833163/
https://ncbi.nlm.nih.gov/pubmed/26382728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12787
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