Effect of CYP3A perpetrators on ibrutinib exposure in healthy participants

Ibrutinib (PCI-32765), a potent covalent inhibitor of Bruton’s tyrosine kinase, has shown efficacy against a variety of B-cell malignancies. Given the prominent role of CYP3A in ibrutinib metabolism, effect of coadministration of CYP3A perpetrators with ibrutinib was evaluated in healthy adults. Ibr...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Pharmacol Res Perspect
Huvudupphovsmän: de Jong, Jan, Skee, Donna, Murphy, Joe, Sukbuntherng, Juthamas, Hellemans, Peter, Smit, Johan, de Vries, Ronald, Jiao, Juhui James, Snoeys, Jan, Mannaert, Erik
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley & Sons, Ltd 2015
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492731/
https://ncbi.nlm.nih.gov/pubmed/26171235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.156
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk