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Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man
AIMS: Saquinavir is a potent HIV protease inhibitor whose effectiveness is limited in vivo by its low bioavailability. Since saquinavir is metabolized by CYP3A4, the effect of grapefruit juice, an inhibitor of CYP3A4, was investigated on its bioavailability. METHODS: After an overnight fast, eight h...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1873963/ https://ncbi.nlm.nih.gov/pubmed/9578182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.t01-1-00687.x |
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