The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1

The J-binding protein 1 (JBP1) is essential for biosynthesis and maintenance of DNA base-J (β-d-glucosyl-hydroxymethyluracil). Base-J and JBP1 are confined to some pathogenic protozoa and are absent from higher eukaryotes, prokaryotes and viruses. We show that JBP1 recognizes J-containing DNA (J-DNA...

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Detalhes bibliográficos
Main Authors: Heidebrecht, Tatjana, Christodoulou, Evangelos, Chalmers, Michael J., Jan, Sabrina, ter Riet, Bas, Grover, Rajesh K., Joosten, Robbie P., Littler, Dene, van Luenen, Henri, Griffin, Patrick R., Wentworth, Paul, Borst, Piet, Perrakis, Anastassis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141245/
https://ncbi.nlm.nih.gov/pubmed/21415010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr125
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