Glucosylated Hydroxymethyluracil, DNA Base J, Prevents Transcriptional Readthrough in Leishmania

Some Ts in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (β-D-glucosyl-hydroxymethyluracil). In Leishmania, about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA polymerase II ter...

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Autori principali: van Luenen, Henri G.A.M., Farris, Carol, Jan, Sabrina, Genest, Paul-Andre, Tripathi, Pankaj, Velds, Arno, Kerkhoven, Ron M., Nieuwland, Marja, Haydock, Andrew, Ramasamy, Gowthaman, Vainio, Saara, Heidebrecht, Tatjana, Perrakis, Anastassis, Pagie, Ludo, van Steensel, Bas, Myler, Peter J., Borst, Piet
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684241/
https://ncbi.nlm.nih.gov/pubmed/22939620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.030
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