Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma brucei

Base J, β-d-glucosyl-hydroxymethyluracil, is an epigenetic modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. J is enriched at sites involved in RNA polymerase (RNAP) II initiation and termination. Reduction of J in Leishmania tarentolae via growth in Brd...

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Autores principales: Reynolds, David, Cliffe, Laura, Förstner, Konrad U., Hon, Chung-Chau, Siegel, T. Nicolai, Sabatini, Robert
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150806/
https://ncbi.nlm.nih.gov/pubmed/25104019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku714
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