Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

ABCB5 is an ABC transporter that was shown to confer low-level multidrug resistance in cancer. In this study, we show that ABCB5 was mutated in 13.75% of the 640 melanoma samples analyzed. Besides nonsense mutations, two mutation hotspots were found in the ABCB5 protein, in the drug-binding pocket a...

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Udgivet i:J Invest Dermatol
Main Authors: Sana, Géraldine, Madigan, James P., Gartner, Jared J., Fourrez, Marie, Lin, Jimmy, Qutob, Nouar, Narayan, Jitendra, Shukla, Suneet, Ambudkar, Suresh V., Xia, Di, Rosenberg, Steven A., Gottesman, Michael M., Samuels, Yardena, Gillet, Jean-Pierre
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708748/
https://ncbi.nlm.nih.gov/pubmed/30905807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2019.01.036
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