Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens

The antigenicity of cells is demarcated by the peptides bound by their Human Leucocyte Antigen (HLA) molecules. Through this antigen presentation, T cell specificity response is controlled. As a fraction of the expressed mutated peptides is presented on the HLA, these neo-epitopes could be immunogen...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Kalaora, Shelly, Barnea, Eilon, Merhavi-Shoham, Efrat, Qutob, Nouar, Teer, Jamie K., Shimony, Nilly, Schachter, Jacob, Rosenberg, Steven A., Besser, Michal J., Admon, Arie, Samuels, Yardena
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868674/
https://ncbi.nlm.nih.gov/pubmed/26819371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6960
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