Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

BACKGROUND: Targeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is a crucial need to r...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Besser, Hanan, Yunger, Sharon, Merhavi-Shoham, Efrat, Cohen, Cyrille J., Louzoun, Yoram
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532181/
https://ncbi.nlm.nih.gov/pubmed/31118084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0595-z
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