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Mutations in a dominant Nef epitope of SIVmac diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding()
Viruses like HIV and SIV escape from containment by CD8(+) T lymphocytes through generating mutations that interfere with epitope peptide:MHC class I binding. However, mutations in some viral epitopes are selected for that have no impact on this binding. We have explored the mechanism underlying the...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175636/ https://ncbi.nlm.nih.gov/pubmed/21841125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101080 |
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