Mechanism of β(2)AR regulation by an intracellular positive allosteric modulator

Drugs targeting the orthosteric, primary binding site of G-protein coupled receptors are the most common therapeutics. Allosteric binding sites, elsewhere on the receptors, are less well-defined, and so less exploited clinically. We report the crystal structure of the prototypic beta-2 adrenergic re...

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Pubblicato in:Science
Autori principali: Liu, Xiangyu, Masoudi, Ali, Kahsai, Alem W., Huang, Li-Yin, Pani, Biswaranjan, Staus, Dean P., Shim, Paul J., Hirata, Kunio, Simhal, Rishabh K., Schwalb, Allison M., Rambarat, Paula K., Ahn, Seungkirl, Lefkowitz, Robert J., Kobilka, Brian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705129/
https://ncbi.nlm.nih.gov/pubmed/31249059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw8981
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