Mechanism of intracellular allosteric β(2)AR antagonist revealed by X-ray crystal structure

G-protein-coupled receptors (GPCRs) pose challenges for drug discovery efforts because of the high degree of structural homology in the orthosteric pocket, particularly for GPCRs within a single subfamily, such as the nine adrenergic receptors. Allosteric ligands may bind to less-conserved regions o...

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Bibliographic Details
Published in:Nature
Main Authors: Liu, Xiangyu, Ahn, Seungkirl, Kahsai, Alem W., Meng, Kai-Cheng, Latorraca, Naomi R., Pani, Biswaranjan, Venkatakrishnan, A. J., Masoudi, Ali, Weis, William I., Dror, Ron O., Chen, Xin, Lefkowitz, Robert J., Kobilka, Brian K.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818265/
https://ncbi.nlm.nih.gov/pubmed/28813418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23652
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