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pH-Dependent Fibril Maturation of a Pmel17 Repeat Domain Isoform Revealed by Tryptophan Fluorescence
The pre-melanosomal protein (Pmel17) aggregates within melanosomes to form functional amyloid fibrils that facilitate melanin polymerization. The repeat domain (RPT) of Pmel17 fibrillates under strict acidic melanosomal pH. Alternative splicing results in a shortened repeat domain (sRPT), which also...
Gorde:
| Argitaratua izan da: | Biochim Biophys Acta Proteins Proteom |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6700743/ https://ncbi.nlm.nih.gov/pubmed/30716507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2019.01.012 |
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