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pH-Dependent Fibril Maturation of a Pmel17 Repeat Domain Isoform Revealed by Tryptophan Fluorescence
The pre-melanosomal protein (Pmel17) aggregates within melanosomes to form functional amyloid fibrils that facilitate melanin polymerization. The repeat domain (RPT) of Pmel17 fibrillates under strict acidic melanosomal pH. Alternative splicing results in a shortened repeat domain (sRPT), which also...
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| Pubblicato in: | Biochim Biophys Acta Proteins Proteom |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6700743/ https://ncbi.nlm.nih.gov/pubmed/30716507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2019.01.012 |
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