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pH-Dependent Fibril Maturation of a Pmel17 Repeat Domain Isoform Revealed by Tryptophan Fluorescence
The pre-melanosomal protein (Pmel17) aggregates within melanosomes to form functional amyloid fibrils that facilitate melanin polymerization. The repeat domain (RPT) of Pmel17 fibrillates under strict acidic melanosomal pH. Alternative splicing results in a shortened repeat domain (sRPT), which also...
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| Publicado no: | Biochim Biophys Acta Proteins Proteom |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6700743/ https://ncbi.nlm.nih.gov/pubmed/30716507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2019.01.012 |
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