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Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17
Pmel17 is a functional amyloidogenic protein whose fibrils act as scaffolds for pigment deposition in human skin and eyes. We have used the repeat domain (RPT, residues 315–444), an essential luminal polypeptide region of Pmel17, as a model system to study conformational changes from soluble unstruc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003087/ https://ncbi.nlm.nih.gov/pubmed/21106765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006424107 |
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