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Probing Fibril Dissolution of the Repeat Domain of a Functional Amyloid, Pmel17, on the Microscopic and Residue Level

Pmel17 is a human amyloid involved in melanin synthesis. A fragment of Pmel17, the repeat domain (RPT) rich in glutamic acids, only forms amyloid under mildly acidic pH. Unlike pathological amyloids, these fibrils dissolve at neutral pH, supporting a reversible aggregation/disaggregation process. He...

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Bibliografiske detaljer
Main Authors: McGlinchey, Ryan P., Gruschus, James M., Nagy, Attila, Lee, Jennifer C.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232329/
https://ncbi.nlm.nih.gov/pubmed/22092386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201578h
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