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Repeat Domains of Melanosome Matrix Protein Pmel17 Orthologs Form Amyloid Fibrils at the Acidic Melanosomal pH
Most amyloids are pathological, but fragments of Pmel17 form a functional amyloid in vertebrate melanosomes essential for melanin synthesis and deposition. We previously reported that only at the mildly acidic pH (4–5.5) typical of melanosomes, the repeat domain (RPT) of human Pmel17 can form amyloi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048723/ https://ncbi.nlm.nih.gov/pubmed/21148556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197152 |
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