Closing the DNA replication cycle: from simple circular molecules to supercoiled and knotted DNA catenanes

Due to helical structure of DNA, massive amounts of positive supercoils are constantly introduced ahead of each replication fork. Positive supercoiling inhibits progression of replication forks but various mechanisms evolved that permit very efficient relaxation of that positive supercoiling. Some o...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Schvartzman, Jorge B, Hernández, Pablo, Krimer, Dora B, Dorier, Julien, Stasiak, Andrzej
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698734/
https://ncbi.nlm.nih.gov/pubmed/31276584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz586
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