Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes

Chikungunya virus (CHIKV) is an emerging mosquito-borne virus that has caused explosive outbreaks worldwide. Although neutralizing monoclonal antibodies (mAbs) against CHIKV inhibit infection in animals, the contribution of Fc effector functions to protection remains unknown. Here, we evaluated the...

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Vydáno v:Sci Immunol
Hlavní autoři: Fox, Julie M., Roy, Vicky, Gunn, Bronwyn M., Huang, Ling, Fong, Rachel H., Edeling, Melissa A., Mack, Matthias, Fremont, Daved H., Doranz, Benjamin J., Johnson, Syd, Alter, Galit, Diamond, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698136/
https://ncbi.nlm.nih.gov/pubmed/30796092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aav5062
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