Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity

Despite causing outbreaks of fever and arthritis in multiple countries, no countermeasures exist against Mayaro virus (MAYV), an emerging mosquito-transmitted alphavirus. We generated 18 neutralizing mAbs against MAYV, 11 of which had “elite” activity that inhibited infection with EC(50) values of &...

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Detalhes bibliográficos
Publicado no:J Exp Med
Principais autores: Earnest, James T., Basore, Katherine, Roy, Vicky, Bailey, Adam L., Wang, David, Alter, Galit, Fremont, Daved H., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781005/
https://ncbi.nlm.nih.gov/pubmed/31337735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190736
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