Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity

Despite causing outbreaks of fever and arthritis in multiple countries, no countermeasures exist against Mayaro virus (MAYV), an emerging mosquito-transmitted alphavirus. We generated 18 neutralizing mAbs against MAYV, 11 of which had “elite” activity that inhibited infection with EC(50) values of &...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Earnest, James T., Basore, Katherine, Roy, Vicky, Bailey, Adam L., Wang, David, Alter, Galit, Fremont, Daved H., Diamond, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781005/
https://ncbi.nlm.nih.gov/pubmed/31337735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190736
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