Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes

Chikungunya virus (CHIKV) is an emerging mosquito-borne virus that has caused explosive outbreaks worldwide. Although neutralizing monoclonal antibodies (mAbs) against CHIKV inhibit infection in animals, the contribution of Fc effector functions to protection remains unknown. Here, we evaluated the...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Fox, Julie M., Roy, Vicky, Gunn, Bronwyn M., Huang, Ling, Fong, Rachel H., Edeling, Melissa A., Mack, Matthias, Fremont, Daved H., Doranz, Benjamin J., Johnson, Syd, Alter, Galit, Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698136/
https://ncbi.nlm.nih.gov/pubmed/30796092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aav5062
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