Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the development of therapeutic agents, we screened 230 new mouse anti-CHIKV monoclonal antibodies (MAbs) for their ability to inhibit...

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Main Authors: Pal, Pankaj, Dowd, Kimberly A., Brien, James D., Edeling, Melissa A., Gorlatov, Sergey, Johnson, Syd, Lee, Iris, Akahata, Wataru, Nabel, Gary J., Richter, Mareike K. S., Smit, Jolanda M., Fremont, Daved H., Pierson, Theodore C., Heise, Mark T., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630103/
https://ncbi.nlm.nih.gov/pubmed/23637602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003312
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