Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope

We previously developed a panel of neutralizing monoclonal antibodies against Dengue virus (DENV)-1, of which few exhibited inhibitory activity against all DENV-1 genotypes. This finding is consistent with reports observing variable neutralization of different DENV strains and genotypes using serum...

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Autors principals: Austin, S. Kyle, Dowd, Kimberly A., Shrestha, Bimmi, Nelson, Christopher A., Edeling, Melissa A., Johnson, Syd, Pierson, Theodore C., Diamond, Michael S., Fremont, Daved H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464233/
https://ncbi.nlm.nih.gov/pubmed/23055922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002930
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