Potent Dengue Virus Neutralization by a Therapeutic Antibody with Low Monovalent Affinity Requires Bivalent Engagement

We recently described our most potently neutralizing monoclonal antibody, E106, which protected against lethal Dengue virus type 1 (DENV-1) infection in mice. To further understand its functional properties, we determined the crystal structure of E106 Fab in complex with domain III (DIII) of DENV-1...

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Autori principali: Edeling, Melissa A., Austin, S. Kyle, Shrestha, Bimmi, Dowd, Kimberly A., Mukherjee, Swati, Nelson, Christopher A., Johnson, Syd, Mabila, Manu N., Christian, Elizabeth A., Rucker, Joseph, Pierson, Theodore C., Diamond, Michael S., Fremont, Daved H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990716/
https://ncbi.nlm.nih.gov/pubmed/24743696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004072
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