Functional Analysis of Antibodies against Dengue Virus Type 4 Reveals Strain-Dependent Epitope Exposure That Impacts Neutralization and Protection

Although prior studies have characterized the neutralizing activities of monoclonal antibodies (MAbs) against dengue virus (DENV) serotypes 1, 2, and 3 (DENV-1, DENV-2, and DENV-3), few reports have assessed the activity of MAbs against DENV-4. Here, we evaluated the inhibitory activity of 81 new mo...

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Autores principales: Sukupolvi-Petty, Soila, Brien, James D., Austin, S. Kyle, Shrestha, Bimmi, Swayne, Sherri, Kahle, Kristen, Doranz, Benjamin J., Johnson, Syd, Pierson, Theodore C., Fremont, Daved H., Diamond, Michael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754038/
https://ncbi.nlm.nih.gov/pubmed/23785205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01314-13
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