The Fc Region of an Antibody Impacts the Neutralization of West Nile Viruses in Different Maturation States

Flavivirus-infected cells secrete a structurally heterogeneous population of viruses because of an inefficient virion maturation process. Flaviviruses assemble as noninfectious, immature virions composed of trimers of envelope (E) and precursor membrane (prM) protein heterodimers. Cleavage of prM is...

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Detalhes bibliográficos
Main Authors: Lee, Phong D., Mukherjee, Swati, Edeling, Melissa A., Dowd, Kimberly A., Austin, S. Kyle, Manhart, Carolyn J., Diamond, Michael S., Fremont, Daved H., Pierson, Theodore C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838241/
https://ncbi.nlm.nih.gov/pubmed/24109224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02340-13
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