Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

Pleural malignant mesothelioma (MM) is a therapy-resistant cancer affecting the serosal lining of the thoracic cavity. Mutations/deletions of BAP1, CDKN2A, and NF2 are the most frequent genetic lesions in human MM. We introduced various combinations of these deletions in the pleura of conditional kn...

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Vydáno v:Cancer Res
Hlavní autoři: Kukuyan, Anna-Mariya, Sementino, Eleonora, Kadariya, Yuwaraj, Menges, Craig W., Cheung, Mitchell, Tan, Yinfei, Cai, Kathy Q., Slifker, Michael J., Peri, Suraj, Klein-Szanto, Andres J., Rauscher, Frank J., Testa, Joseph R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697648/
https://ncbi.nlm.nih.gov/pubmed/31151962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-4093
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