Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

RATIONALE: Peptidylarginine deiminase type IV (PAD4), an enzyme essential for NET formation (NETosis), is released together with neutrophil extracellular traps (NETs) into the extracellular milieu. It citrullinates histone and holds the potential to citrullinate other protein targets. While NETosis...

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Publicado en:Circ Res
Main Authors: Sorvillo, Nicoletta, de Moraes Mizurini, Daniella, Coxon, Carmen, Martinod, Kimberly, Tilvawala, Ronak, Cherpokova, Deya, Salinger, Ari J., Seward, Robert J., Staudinger, Caleb, Weerapana, Eranthie, Shapiro, Nate I., Costello, Catherine E., Thompson, Paul, Wagner, Denisa D.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697196/
https://ncbi.nlm.nih.gov/pubmed/31248335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314571
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