Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

RATIONALE: Peptidylarginine deiminase type IV (PAD4), an enzyme essential for NET formation (NETosis), is released together with neutrophil extracellular traps (NETs) into the extracellular milieu. It citrullinates histone and holds the potential to citrullinate other protein targets. While NETosis...

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Dades bibliogràfiques
Publicat a:Circ Res
Autors principals: Sorvillo, Nicoletta, de Moraes Mizurini, Daniella, Coxon, Carmen, Martinod, Kimberly, Tilvawala, Ronak, Cherpokova, Deya, Salinger, Ari J., Seward, Robert J., Staudinger, Caleb, Weerapana, Eranthie, Shapiro, Nate I., Costello, Catherine E., Thompson, Paul, Wagner, Denisa D.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697196/
https://ncbi.nlm.nih.gov/pubmed/31248335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314571
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