Peptidylarginine deiminase 4 promotes age-related organ fibrosis

Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory models. We determined that NETosis is more prevalen...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Martinod, Kimberly, Witsch, Thilo, Erpenbeck, Luise, Savchenko, Alexander, Hayashi, Hideki, Cherpokova, Deya, Gallant, Maureen, Mauler, Maximilian, Cifuni, Stephen M., Wagner, Denisa D.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294849/
https://ncbi.nlm.nih.gov/pubmed/28031479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160530
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