Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

RATIONALE: Peptidylarginine deiminase type IV (PAD4), an enzyme essential for NET formation (NETosis), is released together with neutrophil extracellular traps (NETs) into the extracellular milieu. It citrullinates histone and holds the potential to citrullinate other protein targets. While NETosis...

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Détails bibliographiques
Publié dans:Circ Res
Auteurs principaux: Sorvillo, Nicoletta, de Moraes Mizurini, Daniella, Coxon, Carmen, Martinod, Kimberly, Tilvawala, Ronak, Cherpokova, Deya, Salinger, Ari J., Seward, Robert J., Staudinger, Caleb, Weerapana, Eranthie, Shapiro, Nate I., Costello, Catherine E., Thompson, Paul, Wagner, Denisa D.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697196/
https://ncbi.nlm.nih.gov/pubmed/31248335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314571
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