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Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

BACKGROUND: Neutrophil serine proteases have been implicated in coagulation and neutrophil extracellular trap (NET) formation. In human neutrophils, neutrophil elastase (NE) translocates to the nucleus during NETosis and cleaves histones, thus aiding in chromatin decondensation. NE(−/−) mice were sh...

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Foilsithe in:J Thromb Haemost
Main Authors: Martinod, Kimberly, Witsch, Thilo, Farley, Kalamo, Gallant, Maureen, Remold-O’Donnell, Eileen, Wagner, Denisa D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785059/
https://ncbi.nlm.nih.gov/pubmed/26712312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13239
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