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Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

BACKGROUND: Neutrophil serine proteases have been implicated in coagulation and neutrophil extracellular trap (NET) formation. In human neutrophils, neutrophil elastase (NE) translocates to the nucleus during NETosis and cleaves histones, thus aiding in chromatin decondensation. NE(−/−) mice were sh...

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Dettagli Bibliografici
Pubblicato in:J Thromb Haemost
Autori principali: Martinod, Kimberly, Witsch, Thilo, Farley, Kalamo, Gallant, Maureen, Remold-O’Donnell, Eileen, Wagner, Denisa D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785059/
https://ncbi.nlm.nih.gov/pubmed/26712312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13239
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