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Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase

Adenosine triphosphate phosphoribosyltransferase (ATP-PRT) catalyzes the first step in histidine biosynthesis, a pathway essential to microorganisms and a validated target for antimicrobial drug design. The ATP-PRT enzyme catalyzes the reversible substitution reaction between phosphoribosyl pyrophos...

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Publicat a:ACS Chem Biol
Autors principals: Moggré, Gert-Jan, Poulin, Myles B., Tyler, Peter C., Schramm, Vern L., Parker, Emily J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693643/
https://ncbi.nlm.nih.gov/pubmed/28872824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00484
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