Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063

Glucose-stimulated insulin secretion from pancreatic β-cells is controlled by ATP-regulated potassium (K(ATP)) channels composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits. The K(ATP) channel-opener diazoxide is FDA-approved for treating hyperinsulinism and hypoglycemia but suffers from o...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacol Exp Ther
Prif Awduron: Kharade, Sujay V., Sanchez-Andres, Juan Vicente, Fulton, Mark G., Shelton, Elaine L., Blobaum, Anna L., Engers, Darren W., Hofmann, Christopher S., Dadi, Prasanna K., Lantier, Louise, Jacobson, David A., Lindsley, Craig W., Denton, Jerod S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2019
Pynciau:
Drug Discovery and Translational Medicine
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691189/
https://ncbi.nlm.nih.gov/pubmed/31201216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.257204
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