Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

The inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) carries out important physiologic roles in epithelial cells of the kidney, astrocytes in the central nervous system, and stria vascularis of the inner ear. Loss-of-function mutations in KCNJ10 lead to EAST/SeSAME syndrome, which is charact...

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Publicado no:Mol Pharmacol
Main Authors: Kharade, Sujay V., Kurata, Haruto, Bender, Aaron M., Blobaum, Anna L., Figueroa, Eric E., Duran, Amanda, Kramer, Meghan, Days, Emily, Vinson, Paige, Flores, Daniel, Satlin, Lisa M., Meiler, Jens, Weaver, C. David, Lindsley, Craig W., Hopkins, Corey R., Denton, Jerod S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041953/
https://ncbi.nlm.nih.gov/pubmed/29895592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112359
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