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Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590
VU590 was the first publicly disclosed, submicromolar-affinity (IC(50) = 0.2 μM), small-molecule inhibitor of the inward rectifier potassium (Kir) channel and diuretic target, Kir1.1. VU590 also inhibits Kir7.1 (IC(50) ∼ 8 μM), and has been used to reveal new roles for Kir7.1 in regulation of myomet...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5553192/ https://ncbi.nlm.nih.gov/pubmed/28619748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.108472 |
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