Discovery, Characterization, and Structure–Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1

The inward rectifier family of potassium (Kir) channels is comprised of at least 16 family members exhibiting broad and often overlapping cellular, tissue, or organ distributions. The discovery of disease-causing mutations in humans and experiments on knockout mice has underscored the importance of...

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Main Authors: Raphemot, Rene, Lonergan, Daniel F., Nguyen, Thuy T., Utley, Thomas, Lewis, L. Michelle, Kadakia, Rishin, Weaver, C. David, Gogliotti, Rocco, Hopkins, Corey, Lindsley, Craig W., Denton, Jerod S.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Research Foundation 2011
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254186/
https://ncbi.nlm.nih.gov/pubmed/22275899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2011.00075
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