Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

The inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) carries out important physiologic roles in epithelial cells of the kidney, astrocytes in the central nervous system, and stria vascularis of the inner ear. Loss-of-function mutations in KCNJ10 lead to EAST/SeSAME syndrome, which is charact...

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書誌詳細
出版年:Mol Pharmacol
主要な著者: Kharade, Sujay V., Kurata, Haruto, Bender, Aaron M., Blobaum, Anna L., Figueroa, Eric E., Duran, Amanda, Kramer, Meghan, Days, Emily, Vinson, Paige, Flores, Daniel, Satlin, Lisa M., Meiler, Jens, Weaver, C. David, Lindsley, Craig W., Hopkins, Corey R., Denton, Jerod S.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2018
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041953/
https://ncbi.nlm.nih.gov/pubmed/29895592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112359
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