Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063

Glucose-stimulated insulin secretion from pancreatic β-cells is controlled by ATP-regulated potassium (K(ATP)) channels composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits. The K(ATP) channel-opener diazoxide is FDA-approved for treating hyperinsulinism and hypoglycemia but suffers from o...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Kharade, Sujay V., Sanchez-Andres, Juan Vicente, Fulton, Mark G., Shelton, Elaine L., Blobaum, Anna L., Engers, Darren W., Hofmann, Christopher S., Dadi, Prasanna K., Lantier, Louise, Jacobson, David A., Lindsley, Craig W., Denton, Jerod S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691189/
https://ncbi.nlm.nih.gov/pubmed/31201216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.257204
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