Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

The regulatory network of genes and molecules in sleep/wakefulness remains to be elucidated. Here we describe the methodology and workflow of the dominant screening of randomly mutagenized mice and discuss theoretical basis of forward genetics research for sleep in mice. Our high-throughput screenin...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Miyoshi, Chika, Kim, Staci J., Ezaki, Takahiro, Ikkyu, Aya, Hotta-Hirashima, Noriko, Kanno, Satomi, Kakizaki, Miyo, Yamada, Mana, Wakana, Shigeharu, Yanagisawa, Masashi, Funato, Hiromasa
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689935/
https://ncbi.nlm.nih.gov/pubmed/31337678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906774116
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