Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

The regulatory network of genes and molecules in sleep/wakefulness remains to be elucidated. Here we describe the methodology and workflow of the dominant screening of randomly mutagenized mice and discuss theoretical basis of forward genetics research for sleep in mice. Our high-throughput screenin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Miyoshi, Chika, Kim, Staci J., Ezaki, Takahiro, Ikkyu, Aya, Hotta-Hirashima, Noriko, Kanno, Satomi, Kakizaki, Miyo, Yamada, Mana, Wakana, Shigeharu, Yanagisawa, Masashi, Funato, Hiromasa
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689935/
https://ncbi.nlm.nih.gov/pubmed/31337678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906774116
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