Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

The regulatory network of genes and molecules in sleep/wakefulness remains to be elucidated. Here we describe the methodology and workflow of the dominant screening of randomly mutagenized mice and discuss theoretical basis of forward genetics research for sleep in mice. Our high-throughput screenin...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Miyoshi, Chika, Kim, Staci J., Ezaki, Takahiro, Ikkyu, Aya, Hotta-Hirashima, Noriko, Kanno, Satomi, Kakizaki, Miyo, Yamada, Mana, Wakana, Shigeharu, Yanagisawa, Masashi, Funato, Hiromasa
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689935/
https://ncbi.nlm.nih.gov/pubmed/31337678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906774116
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