Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis

The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC interaction. In vitro, GC receptor (GR) expression...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Acta Neuropathol
Huvudupphovsmän: Hoepner, Robert, Bagnoud, Maud, Pistor, Maximilian, Salmen, Anke, Briner, Myriam, Synn, Helen, Schrewe, Lisa, Guse, Kirsten, Ahmadi, Farhad, Demir, Seray, Laverick, Louis, Gresle, Melissa, Worley, Paul, Reichardt, Holger Michael, Butzkueven, Helmut, Gold, Ralf, Metz, Imke, Lühder, Fred, Chan, Andrew
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2019
Ämnen:
Original Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689294/
https://ncbi.nlm.nih.gov/pubmed/31030237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02018-8
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk