Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis

The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC interaction. In vitro, GC receptor (GR) expression...

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Veröffentlicht in:Acta Neuropathol
Hauptverfasser: Hoepner, Robert, Bagnoud, Maud, Pistor, Maximilian, Salmen, Anke, Briner, Myriam, Synn, Helen, Schrewe, Lisa, Guse, Kirsten, Ahmadi, Farhad, Demir, Seray, Laverick, Louis, Gresle, Melissa, Worley, Paul, Reichardt, Holger Michael, Butzkueven, Helmut, Gold, Ralf, Metz, Imke, Lühder, Fred, Chan, Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2019
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689294/
https://ncbi.nlm.nih.gov/pubmed/31030237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02018-8
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