Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis

The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC interaction. In vitro, GC receptor (GR) expression...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Hoepner, Robert, Bagnoud, Maud, Pistor, Maximilian, Salmen, Anke, Briner, Myriam, Synn, Helen, Schrewe, Lisa, Guse, Kirsten, Ahmadi, Farhad, Demir, Seray, Laverick, Louis, Gresle, Melissa, Worley, Paul, Reichardt, Holger Michael, Butzkueven, Helmut, Gold, Ralf, Metz, Imke, Lühder, Fred, Chan, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689294/
https://ncbi.nlm.nih.gov/pubmed/31030237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02018-8
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